Dr. Frasier Crane heard those blues a-calling again and Paramount picked up.

The revamped Frasier, based on the Emmy-winning sitcom, will return for season 2 on Sept. 19 with a two-episode premiere and a new episode premiering weekly.

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The sophomore season will see Dr. Crane return to his radio roots at KACL in Seattle for an episode, featuring previously announced guest stars stepping back into their roles from the original Frasier including Dan Butler as Bob "Bulldog" Briscoe and Edward Hibbert as Gil Chesterton, as well as Harriet Sansom Harris as Frasier’s delightfully devilish agent, Bebe Glazer.

"Dan Butler and Edward Hibbert have made an indelible contribution to television, and I am overjoyed to welcome them back to Frasier and for the opportunity to work together once again," star and producer Kelsey Grammer said in a statement.

Peri Gilpin is also set to reprise her role as Roz Doyle in the upcoming season, joined by previously-announced season 2 guest stars Patricia Heaton, Yvette Nicole Brown, Amy Sedaris, and Grammer's real-life daughter Greer Grammer, who will play Roz's daughter Alice Doyle.

The first season of the reboot also starred Jack Cutmore-Scott as Frasier’s son, Freddy; Nicholas Lyndhurst as Frasier’s college-buddy-turned-university professor, Alan; Toks Olagundoye as Alan’s colleague and head of the psychology department, Olivia; Jess Salgueiro as Frasier's neighbor Eve; and Anders Keith as Frasier’s nephew, David.